YKL-40 is a CSF biomarker of intrathecal inflammation in secondary progressive multiple sclerosis

Chitinase-3-Like Protein 1 (YKL-40) Is a New Biomarker of Inflammation in Psoriasis

PURPOSE The evaluation of new inflammatory biomarkers in psoriasis could determine therapeutic decisions. Chitinase-3-like protein 1 (YKL-40) plays a role in inflammation. The study was undertaken to check whether YKL-40 is a reliable biomarker of inflammation in psoriasis. MATERIALS AND METHODS 55 psoriatic patients were enrolled, including 21 men and 34 women, aged from 18 to 88 years. The ...

Defining secondary progressive multiple sclerosis.

A number of studies have been conducted with the onset of secondary progressive multiple sclerosis as an inclusion criterion or an outcome of interest. However, a standardized objective definition of secondary progressive multiple sclerosis has been lacking. The aim of this work was to evaluate the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis,...

CSF neurofilament light: A universal risk biomarker in multiple sclerosis?

Serum YKL-40, a new prognostic biomarker in cancer patients?

YKL-40, a member of the "mammalian chitinase-like proteins," is expressed and secreted by several types of solid tumors. The exact function of YKL-40 in cancer diseases is unknown and is an important objective of future studies. YKL-40 exhibits growth factor activity for cells involved in tissue remodeling processes. YKL-40 may have a role in cancer cell proliferation, survival, and invasivenes...

Serum YKL-40: A possible biomarker in bronchial asthma?

Background: The evolutionary conserved 18 glycosyl hydrolase family contains chitinases and chitinase like proteins that share amino acid sequence homology with true chitinases but lack enzymatic activity. The chitinase like protein YKL-40, encoded by the chitinase3-like 1 gene (CHI3L1), has been found to be either the cause or a biomarker for asthma. However, its pattern of expression with dis...